Opposing Roles of Integrin 6A 1 and Dystroglycan in Laminin-mediated Extracellular Signal-regulated Kinase Activation

نویسندگان

  • Maria Ferletta
  • Yamato Kikkawa
  • Hao Yu
  • Jan F. Talts
  • Madeleine Durbeej
  • Arnoud Sonnenberg
  • Rupert Timpl
  • Kevin P. Campbell
  • Peter Ekblom
  • Elke Genersch
  • Richard Hynes
چکیده

†Department of Cell and Molecular Biology, Lund University, SE-22184 Lund, Sweden; *Department of Cell and Molecular Biology, Uppsala University, SE-75123 Uppsala, Sweden; ‡Department of Physiology, Biophysics, and Neurology, Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa; §The Netherlands Cancer Institute, Amsterdam, The Netherlands; and Max-PlanckInstitute for Biochemistry, Martinsried, Germany

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منابع مشابه

The Laminins and their Receptors

Ferletta, M. 2002. The Laminins and their Receptors. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 688. 67 pp. Uppsala. ISBN 91-554-5239-6 Basement membranes are thin extracellular sheets that surround muscle, fat and peripheral nerve cells and underlay epithelial and endothelial cells. Laminins are one of the main pr...

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Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation of beta1 integrin-null cells.

The presence of many laminin receptors of the beta1 integrin family on most cells makes it difficult to define the biological functions of other major laminin receptors such as integrin alpha6beta4 and dystroglycan. We therefore tested the binding of a beta1 integrin-null cell line GD25 to four different laminin variants. The cells were shown to produce dystroglycan, which based on affinity chr...

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Dystroglycan receptor is involved in integrin activation in intestinal epithelia.

The dystroglycans (alpha-DG and beta-DG), which play important roles in the formation of basement membranes, have been well studied in skeletal muscle and nerve, but their expression and localization in intestinal epithelial cells has not been previously investigated. Here, we demonstrated that the DG complex, composed of alpha-DG, beta-DG, and utrophin, is specifically expressed in the basolat...

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Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization.

Dystroglycan (DG) is a cell surface receptor for several extracellular matrix (ECM) molecules including laminins, agrin and perlecan. Recent data indicate that DG function is required for the formation of basement membranes in early development and the organization of laminin on the cell surface. Here we show that DG-mediated laminin clustering on mouse embryonic stem (ES) cells is a dynamic pr...

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The Effect of Laminin and Gelatin Extracellular Matrix on Short-Term Cultivation of Neonate Mouse Spermatogonial Stem Cells

Purpose: To compare the effect of laminin and gelatin on short-term culture of spermatogonial stem cells (SSCs) from neonatal mouse testes.Materials and Methods: Cell suspension containing SSCs were isolated from testes of 6 day-old mice and cultured in the presence of Glial-derived neuroterophic factor (GDNF), Epidermal Growth Factor (EGF) and Basic Fibroblastic Growth Factor (bFGF) on laminin...

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تاریخ انتشار 2003